Pathomorphological diagnosis of primary cutaneous CD4-positive small/medium T-cell lymphoproliferative disorder: a 28-case series

Introduction. Primary cutaneous CD4+ lymphoproliferative disorder of small and medium cells (PC T-LPD small/medium cell) is a new entity identified in the WHO classification published 2017. The aim research was to characterize morphological immunohistochemical features PC cell. Materials methods. study examined 28 skin biopsies from 13 males 15 females with cell using histological Results. We detected growth pattern be nodular, focal–diffuse, diffuse types. Each case characterized by significant T-cell lymphoid infiltration an immunophenotype follicular T-helper (Tfh-immunophenotype), number B-cells varying. Conclusion. rare disease that requires further determine criteria for diagnosis treatment. Keywords: primary disorder, T helper cells,